Cancer Therapy: Preclinical Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers
نویسندگان
چکیده
Purpose: PIMkinases have been shown to act as oncogenes inmice, with each familymember being able to drive progressionofhematologic cancers. Consistentwith this,we found that PIMs are highly expressed in human hematologic cancers and show that each isoform has a distinct expression pattern among disease subtypes. This suggests that inhibitors of all three PIMs would be effective in treating multiple hematologic
منابع مشابه
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
PURPOSE PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that each isoform has a distinct expression pattern among disease subtypes. This suggests that inhibitors of all three PIMs would be effective in treati...
متن کاملPim kinases in hematological malignancies: where are we now and where are we going?
The proviral insertion in murine (PIM) lymphoma proteins are a serine/threonine kinase family composed of three isoformes: Pim-1, Pim-2 and Pim-3. They play a critical role in the control of cell proliferation, survival, homing and migration. Recently, overexpression of Pim kinases has been reported in human tumors, mainly in hematologic malignancies. In vitro and in vivo studies have confirmed...
متن کاملThiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
The PIM family of serine/threonine kinases have become an attractive target for anti-cancer drug development, particularly for certain hematological malignancies. Here, we describe the discovery of a series of inhibitors of the PIM kinase family using a high throughput screening strategy. Through a combination of molecular modeling and optimization studies, the intrinsic potencies and molecular...
متن کاملThe Therapeutic Effect of Statins on Survival of Patients with Gastrointestinal Cancer: a Review
Cancer -can significantly have ruining effects on very high of human beings, social, and economic condition. Gastrointestinal (GI) cancer has been reported as one of the most prevalent cancers and the incidence rates of this disorder is increasing across the world. This review explains practical recommendations for the management and improvement of patients with GI cancer by statins. Statins, a...
متن کاملThe Therapeutic Effect of Statins on Survival of Patients with Gastrointestinal Cancer: a Review
Cancer -can significantly have ruining effects on very high of human beings, social, and economic condition. Gastrointestinal (GI) cancer has been reported as one of the most prevalent cancers and the incidence rates of this disorder is increasing across the world. This review explains practical recommendations for the management and improvement of patients with GI cancer by statins. Statins, a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014